Latin: Piper longum

Therapeutic Action:

Piper Longum is most commonly used to treat respiratory infections such as stomachache, bronchitis, diseases of the spleen, cough, tumors, and asthma. When applied topically, it soothes and relieves muscular pains and inflammation. In Ayurvedic medicine, it is said to be a good rejuvenator. Piper Longum helps stimulate the appetite and it dispels gas from the intestines. An infusion of Piper Longum root is used after birth to induce the expulsion of the placenta. Actions and Uses : Antiallergic activity of the fruit has been studied. It effectively reduced passive cutaneous anaphylaxis in rats and protected guinea pigs against antigen-induced bronchospasm; a 30% protection of mast cells was observed in an in-vitro study. Both alcoholic extract and piplartine extracted from the stems showed significant inhibition of ciliary movements of oesophagus of frog. Neogi et al studied the pharmacology of piperine. Piperine decreased the rate and amplitude of respiration and showed nonspecific blockade of acetylcholine, histamine and 5-hydroxytryptamine induced spasm on isolated guinea pig and rabbit intestine. The oil of fruit has been found to possess significant paralytic action on the nerve-muscle pre- paration of A. lumbricoides. The hepatoprotective effect has been shown in carbon tetrachloride-induced liver damage in rats. A common use of the fruit is in the prevention of recurrent attacks of bronchial asthma. Another important indication is in chronic malaria. In a study of 240 children with a long term use of fruit 58.3% had decreased severity of attacks. In another study 20 children were studied for one year with the same treatment. Eleven had no recurrence. All patients had strongly positive skin test which became negative in 6 and decreased significantly in 12 after five weeks of treatment. Along with Piper nigrum and C. officinale it has been useful in viral hepatitis. Piper longum is in widespread use for many centuries. The standard doses are well tolerated. No mortality was observed with the powder of the fruit boiled in milk and water administered orally to albino rats in a dose of 1 gm/kg. Acute toxicity studies with piperine.


  • Nadkarni, Vol I Page 965-969
  • Database Vol 3 Page 473
  • Paranjape Page 202-204

Used in:

  • Entrox Forte Tablets / Entrox Tablets / Ferolin Forte Tablets
  • Unexozim Forte Capsule

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